TRIM38 directly binds to TAB2, and recognizes the K63 of RIP1 in the TNF-α signaling pathway through TAB2 to connect the ubiquitin chain or TRAF6 in the IL-1β signaling pathway, thereby inhibiting the key pathway TAK1-MAPK cascade in the process of liver fibrosis (96). This evidence concerns the gene MAP3K7 and Hepatic fibrosis.