However, studies have shown that TRIM family members can also inhibit the occurrence of MAFLD, such as TRIM31 facilitates the degradation of Rhbdf2 through k48-linked polyubiquitination, This action inhibits the Rhbdf2-MAP3K7 signaling pathway and downstream events mitigating insulin resistance, liver steatosis, inflammation and liver fibrosis caused by genetic factors and high-caloric diets (135). The gene discussed is RHBDF2; the disease is Insulin resistance.