FAM209B significantly enriched the functions of regulation of inflammatory response, the pathway of antigen processing, and presentation, while the humoral immune response, immunoglobulin complex, and the pathways of some autoimmune diseases like Alzheimer’s disease and Parkinson’s disease were highly enriched by POM121L1P and PTGES. A literature reported that the microsomal PTGES-1/PGE axis promotes the process of wound repair by gathering regulatory T cells (31). Here, FAM209B is linked to Alzheimer disease.