The black module was associated with extracellular structure organization, ECM–receptor interactions, focal adhesion, and the PI3K–Akt signaling pathway, while the brown module was associated with the ERK1 and ERK2 cascades, the ERBB signaling pathway, responses to chemokines, responses to interleukin−1, asthma, staphylococcus aureus infections, leishmaniasis, and hematopoietic cell lineages. The gene discussed is MAPK3; the disease is staphylococcus aureus infection.