MAPT and early-onset autosomal dominant Alzheimer disease: Our aims, using this new approach on MR scans within the DIAN‐Obs cohort were to: (1) identify differences in the T1w and FLAIR cortical intensity distribution in individuals with dominantly inherited Alzheimer disease‐causing mutations versus non‐carrier controls; (2) explore changes in the T1w and FLAIR cortical intensity distribution in individuals with these mutations along the disease trajectory from the asymptomatic to symptomatic stage; and (3) identify any relationship between these MR signal changes and amyloid and tau pathology as measured by amyloid PET and tau PET, respectively.