Orange and blue brain regions respectively show regions with a significant increase or decrease in our new MR intensity‐based biomarkers (T1 Mu, T1 sigma, FLAIR mu and FLAIR sigma) or the conventional PET imaging biomarkers (Tau PET and Amyloid PET), when compared between mutation carriers versus  non‐carriers of dominantly‐inherited Alzheimer disease. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.