Furthermore, besides the H3K27Ac, the effect of transcription factor and enhancer after the histone modification is also worth to investigating; the transcription factor binding prediction on the promoter of LINC00501 revealed that numerous transcription factors may also participate in the regulation of LINC00501, including NF‐κB, YY1, GATA245, 46, 47 which have already been reported to prompt gastric cancer invasion and progression. The gene discussed is NFKB1; the disease is gastric cancer.