Cluster analysis of all ion channels in the transcriptome sequencing data indicated that basal Piezo1 messenger RNA level was the most abundantly expressed channel and was prominently upregulated in the BOO bladder compared to the sham‐operated bladder (Figure 4B,C), whose variation trend of Piezo1 was similar to BPH bladder (Figure S4, Supporting Information). The gene discussed is PIEZO1; the disease is benign prostatic hyperplasia.