The ischemic stroke was induced by photothrombosis in the cerebral cortex of SCID mice in which the ischemic cavity was surrounded by GFAP+ and S100β+ glial scar at day 14 (Figure 1c; Figure S1b–h, Supporting Information) and the cortex collapsed at day 30 without treatment (Figure S1i, Supporting Information). Here, S100B is linked to ischemic stroke.