Although CD73 has been reported to promote gemcitabine resistance in pancreatic cancer cells, its role in gemcitabine resistance is mediated by its ecto‐5′‐nucleotidase‐independent functions by regulating CD73 expression through knockdown and overexpression.[28] However, AB680 could not regulate the expression of CD73 in tumor cells, and exert anti‐tumor effects by inhibiting its enzyme activity. This evidence concerns the gene NT5E and pancreatic neoplasm.