A previous study also demonstrated the synergistic anti‐tumor effect of targeting CD73 and PD‐1 in mouse models of colorectal cancer.[21] Therefore, we further explored whether inhibiting CD73 activity with AB680 to increase tumor‐infiltrating CD8+ T cells could improve the efficacy of anti‐PD‐1 treatment in PDAC (Figure 5A). This evidence concerns the gene CD8A and neoplasm.