A previous study identified the specific binding of AMP to the adenosine A1 receptor (ADORA1),[34] and ADORA1 was found to promote tumor progression via the PI3K/AKT signaling pathway.[35] Activation of the AKT signaling pathway effectively promotes SOX9 expression,[36] which has been reported to transcriptionally regulate CXCL5 expression.[29, 37] Therefore, we speculated that AMP might upregulate CXCL5 expression through the ADORA1/AKT/SOX9 axis, which will be further verified in our subsequent study. Here, ADORA1 is linked to neoplasm.