The extracellular cystine is imported into the cell through SLC7A11, whereas SLC3A2 anchors SLC7A11 to the plasma membrane and maintains SLC7A11 protein stability.[60] In addition, we observed that SLC7A11 was O‐GlcNAcylated by the USP8‐OGT axis in HCC cells, and O‐GlcNAcylation of SLC7A11 is essential for its functions to absorb cystine. Here, SLC3A2 is linked to hepatocellular carcinoma.