The extracellular cystine is imported into the cell through SLC7A11, whereas SLC3A2 anchors SLC7A11 to the plasma membrane and maintains SLC7A11 protein stability.[60] In addition, we observed that SLC7A11 was O‐GlcNAcylated by the USP8‐OGT axis in HCC cells, and O‐GlcNAcylation of SLC7A11 is essential for its functions to absorb cystine. The gene discussed is SLC7A11; the disease is hepatocellular carcinoma.