A recent study demonstrated that the suppression of USP8 sensitizes cancer cells to ferroptosis through up‐regulating ferritinophagy and intracellular iron levels in a SQSTM1‐NCOA4‐ferritin dependent manner.[70] We also observed that ectopic expressed OGT or SLC7A11 in USP8 knockout LM3 cells only partially recovered the cell death induced by RSL3, indicating some other proteins regulated by USP8 and OGT may also contribute to ferroptosis resistance. This evidence concerns the gene SQSTM1 and cancer.