One study in rats revealed a similar 5‐HT receptor (HTR2C and HTR1A)‐mediated mechanism underlying the hypothalamic programming of obesity susceptibility by maternal protein restriction during gestation.[64] Body weight is affected by both hedonic and homeostatic hunger systems.[65] Hypothalamic dopamine and opioid‐related circuitry were implicated in affecting animals’ preference for palatable foods through reward mechanisms.[66, 67] We found that the expression of genes related to opioid and dopamine signaling was downregulated by maternal HFD in females but not in males. The gene discussed is HTR1A; the disease is obesity due to melanocortin 4 receptor deficiency.