One study in rats revealed a similar 5‐HT receptor (HTR2C and HTR1A)‐mediated mechanism underlying the hypothalamic programming of obesity susceptibility by maternal protein restriction during gestation.[64] Body weight is affected by both hedonic and homeostatic hunger systems.[65] Hypothalamic dopamine and opioid‐related circuitry were implicated in affecting animals’ preference for palatable foods through reward mechanisms.[66, 67] We found that the expression of genes related to opioid and dopamine signaling was downregulated by maternal HFD in females but not in males. This evidence concerns the gene HTR2C and obesity due to melanocortin 4 receptor deficiency.