HTR1A and obesity due to melanocortin 4 receptor deficiency: However, studies have shown that the hypothalamic 5‐HT system plays an anorectic role at least through its receptors including HTR2C, HTR1A, and HTR1B.[60, 61, 62, 63] For example, HTR2C deficiency specifically in POMC neurons promoted hyperphagia and HFD‐induced obesity.[60] Thus, the downregulation of these 5‐HT receptors may act as a common cause of the increased risk of obesity in offspring mice independent of sex.