LEP and overnutrition: Hence together these hormones may program the development of hypothalamic feeding circuits.[37] Interestingly, the hypothalamic response to leptin and ghrelin can be impaired by maternal/neonatal overnutrition.[83] These metabolic hormones in early postnatal offspring can be affected by their nutritional status and accelerated body weight gain, thus may play important roles in the (sex differential) hypothalamic developmental programing.[84, 85] The sex differences in these kinds of developmental programing of metabolism related to hypothalamic control have also been observed.[84]