To further verify the ability of Fe65-EXO to enhance the bioavailability of Cory-B in the brain of AD mice, the amount of Cory-B was examined in the brain relative to that in the plasma by liquid chromatography-mass spectroscopy (LC–MS) analysis of biofluid from the brain and plasma (Supplementary Fig. S13a–f). The gene discussed is PPIB; the disease is Alzheimer disease.