The autophagosome is then moved to the lysosome, where it merges with the lysosome membrane to break down the contents of the autophagosome.27–29 Therefore, we examined whether Fe65-EXO-Cory-B could enter neuron cells through APP receptor-dependent endocytosis and induce autophagy via BECN1, ATG5, and ATG7 to reduce AD pathology and improve cognitive and locomotor behavior. This evidence concerns the gene APBB1 and Alzheimer disease.