Our results demonstrated that Fe65-EXO-Cory-B injected intravenously could reach the target site, evidenced by APP overexpressed neuronal cells in the AD mice brain (Fig. 4a–t), without any noticeable toxicity to major organs including the brain in an AD mice model (Supplementary Figs. S14, 15, 16). The gene discussed is APP; the disease is Alzheimer disease.