The enhanced protein level of LC3B-II and reduced SQSTM1 in the brain of 5xFAD mice injected with Fe65-EXO-Cory-B established its ability to augment autophagy, leading to the decreased level of APP-CTF (Supplementary Fig. S8a–d), Aβ and amyloid plaque in the brain of 5xFAD mice (Supplementary Figs. S9a–d, S10a–d). The gene discussed is APP; the disease is amyloidosis.