FBXW7 and neoplasm: FBXW7 is the most recurrently mutated F‐box gene in human cancer, acting as a tumour suppressor, being commonly mutated, deleted or hypermethylated across cancer types, notably endometrial (~ 20%) and colorectal (17.5%) subtypes [4, 5, 6, 7, 8, 9, 10].