FBXW7 and colorectal neoplasm: For example, when we assessed the relationship between CDC7 gene dependency and FBXW7 mRNA expression in 43 colorectal tumour cell lines profiled using genome‐wide shRNA libraries as part of the DepMap initiative, we noted a positive correlation, Pearson's correlation R = 0.3 and a linear regression P = 0.051 (i.e. tumour cell lines with reduced FBXW7 mRNA exhibited greater dependency upon CDC7, Fig. S2C).