As shown in Figure 6C, most phosphorylated proteins downregulated by TalaA are important transcription factors in cancer cells (e.g., JUN, NFATC1), translation regulatory elements (eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) and EIF4ENIF1), or important signal transduction molecules of cancer cells (e.g., ABL1, ribosomal protein S6 kinase B1 (RPS6KB1)); the phosphorylated protein exhibiting the most significant upregulation was EEF2 at Thr57 and Thr59. The gene discussed is EIF4ENIF1; the disease is cancer.