To validate these findings in a more physiologically relevant setting, we conducted experiments in an autochthonous model of NSCLC, utilizing the KrasG12D; p53flox/flox (KP) lung adenocarcinoma system, which can be induced through lentiviral delivery of Cre recombinase alone or in combination with TRIM28 (Fig. 6C). The gene discussed is TRIM28; the disease is lung adenocarcinoma.