The AMPK/mTORC1/NLRP3 signaling axis is also one of the signaling pathways that mediate pyroptosis of podocyte, and fucoidan (FPS), a class of sulfated carbohydrates found in brown marine algae and echinoderms, has been found to alleviate podocyte damage in diabetic nephropathy by modulating this pathway [85]. This evidence concerns the gene NLRP3 and diabetic kidney disease.