In the univariate analysis, several variables were found to have a significant impact on OS (Table 4), including histology, stage, primary site surgery, regional lymph node dissection, chemotherapy, radiation, liver metastases, lung metastases, grade, pretreatment CEA, perineural invasion, and tumor size which are also related to CSS (Supplementary Table S7). The gene discussed is CEACAM5; the disease is neoplasm.