The mRNA expression levels of genes characteristics of a tumor-supportive macrophage phenotype, including Arg-1, were also downregulated by shMYBL2-CM, while those of the cytotoxic response-related genes IL-1β, IL-12 A, and CD86 were increased by supernatants of shMYBL2 cells (Fig. 3H). The gene discussed is ARG1; the disease is neoplasm.