It has been reported that mutations in many gene families such as Msh homeobox 1 (MSX1), fibroblasts growth factor (FGF), paired box 9 (PAX9), ectodysplasin A (EDA), bone morphogenetic proteins (BMP), runt-related transcription factor 2 (RUNX2), adenomatous polyposis coli (APC), sonic hedgehog signaling molecule (SHH) may play a role in the origin of different developmental dental anomalies [21–24]. The gene discussed is RUNX2; the disease is Abnormality of the dentition.