Specifically, the increased abundance of 3 proteins was significantly associated with an increased risk of PD, including GPNMB (OR:1.464, 95%CI: 1.280–1.675, P = 2.48E-08), SEC23IP (OR:7.880, 95%CI: 3.020–20.559, P = 2.45E-05) and ARSA (OR: 1.938,95%CI:1.394–2.696, P = 8.37E-05), while the increased protein abundance of the other 3 genes was significantly associated with a decreased risk of PD, namely CD38 (OR:0.319, 95%CI:0.237–0.431, P = 6.99E-14), DGKQ (OR:0.136 95%CI:0.071–0.261, P = 1.97E-09), and CTSB (OR:0.300, 95%CI: 0.092–0.433, P = 4.39E-05). Here, CTSB is linked to Parkinson disease.