Moreover, by performing PPI with known PD-causative genes, we found that the top significant genes could interact with several known PD-causative genes, such as GPNMB with LRRK2, SEC23IP with DNAJC13, ARSA with GBA and CD38 with UCHL1 (Fig. 2a). The gene discussed is LRRK2; the disease is Parkinson disease.