However, the other PATs, such as ZDHHC6 (preferentially expressed in podocytes) (Fig. 2d) and ZDHHC1, 2, 5 (up-regulated in the fibrotic kidneys) (Fig. 2b, Supplementary Fig. 2 and Fig. 3), may also contribute to renal fibrosis by regulating palmitoylation of different substrates in various cell types. The gene discussed is ZDHHC6; the disease is renal fibrosis.