Jeong and Yoo treated 14 tumor cell lines and a colorectal cancer murine model with a TRAIL/ANGPT1-co-expressing oncolytic vaccinia virus, showing that the dual expression of these molecules was effective in inducing apoptosis and inhibiting tumor growth in the in vivo assays, followed by caspase 3 and CD8 expression in tumors30. This evidence concerns the gene CASP3 and colorectal cancer.