HLA-S and head and neck squamous cell carcinoma: Interestingly, genetic screening showed that individual molecular markers such as PD-1, MICA, CEACAM-1, or HLAs struggled to predict NK cell cytotoxicity (both primary ML-NK cells and NK cell lines) against patient-derived HNSCC samples (Supporting Fig. 3), suggesting that a more holistic approach that integrates multiple markers could help us to successfully predict NK cell sensibility.