TNF and rheumatoid arthritis: Ingenuity Pathway Analysis revealed that genes associated with the inflammatory response, including pathogen-induced cytokine storm signaling, OA pathway and role of osteoblasts and osteoclasts in rheumatoid arthritis signaling, as well as genes associated with the phagosome formation pathway, were enhanced in Notch2tm1.1Ecan chondrocytes compared to control, both treated with TNFα (Fig. 8).