CCL8 and tuberculosis: Transcriptomic measurements from ΔpcaA-infected C3HeB/FeJ lungs showed upregulation of genes (Ccl2 and Cxcl10) associated with an incipient TB signature in humans31,32 as well as stimulatory chemokines for monocyte and neutrophil infiltration (Ccl7, Ccl8, Cxcl1, and Cxcl2) (Figure 2A, upper), consistent with the observed pathology (Figures S2A and S2B).