We had previously shown that MCL-1 inhibitors that significantly reduce M.tb growth in macrophages did not effectively reduce M.tb growth in our pre-clinical granuloma model, whereas inhibition of MCL-1, BCL-2, and BCL-XL with pan MCL-1 family inhibitors did [15], suggesting that these general inhibitors more effectively penetrated the granuloma structure and/or that inhibition of MCL-1, BCL-2, and BCL-XL is required when the bacteria are in multicellular complexes. This evidence concerns the gene BCL2L1 and Granuloma.