Kadeli et al. prospectively evaluated the influence of STTA (40 mg) on PG (fasting PG [FPG] and HbA1c), cortisol, and adrenocorticotrophic hormone (ACTH) in 33 patients with type 2 diabetic mellitus and DME; they found that STTA did not significantly change the FPG, HbA1c, cortisol, and ACTH levels as compared with those in the controls (ST injection of saline solution) [8]. Here, POMC is linked to type 2 diabetes mellitus.