To further explore the effect of Dyrk1A on the cell apoptosis, we performed overexpression and knockdown of Dyrk1A in U87 cells (Human glioma cell line) and then treated the cells with 1.2 mM or 1.5 mM H2O2 for 2 h to induce apoptosis. The gene discussed is DYRK1A; the disease is glioma.