CircRNA spliceosome‐associated cyclophilin (circCwc27), derived from the CWC27 gene, was highly expressed in neurons, upregulated in the temporal cortex and plasma of APP/PS1 mice and AD patients and has an impact on cognition, neuropathology, and transcriptome in APP/PS1 mice.59 The gene discussed is PSEN1; the disease is Alzheimer disease.