For example, circ‐Hdgfrp3 took part in protecting neuronal function and integrity in neuronal cells, whereas mutant FUS protein (mtFUS) affected the localization of circ‐Hdgfrp3 under oxidative stress conditions.95 The mtFUS could lead to abnormal accumulation of cytoplasmic FUS protein and increased mitochondrial translocation, resulting in excessive mitochondrial fission and damage, eventually leading to neuronal death, which was a major pathological feature in some ALS patients.12 This evidence concerns the gene HDGFL3 and amyotrophic lateral sclerosis.