Indeed, Wg signaling is dysregulated in ALS [161, 162], mRNAs associated with Wg/Wnt pathway are enriched in FTD patient frontal cortices [115] and WNT1 and Granulin (GRN), an FTD linked gene, have been shown to regulate each others’ expression in human neuronal progenitors [163]. This evidence concerns the gene WNT1 and amyotrophic lateral sclerosis.