GPC6 and frontotemporal dementia: Further substantiating these findings, we found that the expression of GPC6 mRNA, a human ortholog of dlp, is altered in FTD patient brains [94], specifically in neuronal nuclei that exhibit the molecular signature of TDP-43 depletion (i.e., cryptic exon inclusion in specific TDP-43 transcriptional targets), consistent with a link between Dlp/GPC6 and TDP-43 pathology.