LGALS4 and amyotrophic lateral sclerosis: Consistent with these findings, we found that nearly 44% of TDP-43WT OE and 42% of TDP-43G298S OE highly associated mRNAs in MBNs overlapped with those we identified previously in motor neurons (MNs) when modeling ALS by overexpressing TDP-43 with the D42 GAL4 driver (Fig. 6b, Additional file 1: Fig. S6-supplement 1c).