Indeed, Wg signaling is dysregulated in ALS [161, 162], mRNAs associated with Wg/Wnt pathway are enriched in FTD patient frontal cortices [115] and WNT1 and Granulin (GRN), an FTD linked gene, have been shown to regulate each others’ expression in human neuronal progenitors [163]. Here, GRN is linked to amyotrophic lateral sclerosis.