Interestingly, among the latter, we identified dlp mRNA, encoding the heparan sulfate proteoglycan (HSPG) Dally-like protein (Dlp)/GPC6, which we previously found to be a target of TDP-43 in fly models of ALS and is altered in human ALS spinal cords [38]. This evidence concerns the gene CD44 and amyotrophic lateral sclerosis.