Interestingly, among the latter, we identified dlp mRNA, encoding the heparan sulfate proteoglycan (HSPG) Dally-like protein (Dlp)/GPC6, which we previously found to be a target of TDP-43 in fly models of ALS and is altered in human ALS spinal cords [38]. The gene discussed is GPC6; the disease is amyotrophic lateral sclerosis.