There was no evidence of transmission of a prion disease when rostral medulla and cerebellum of TSE suspect 6/17 were inoculated in transgenic mice: neither TSE-specific vacuolation nor accumulation of disease-specific PrP accumulation were demonstrated by histopathology and immunohistochemistry although some were judged to display signs of a TSE (Table 4). Here, PRNP is linked to prion disease.