Importantly, WNT3-overexpression also rescued the CFC production and IM response of CML CD34+ cells (n = 4) (Fig. 6K, L).Thus, the current study demonstrated that a conserved ZFX/WNT3 axis modulates the growth and IM response of BCR/ABL+ cells. The gene discussed is BCR; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.