Taken together, the present study revealed a pivotal role of the ZFX/WNT3 axis in CML stem/progenitor cells, which activates WNT3/β-catenin signaling to promote the growth of these cells and confer IM resistance to these cells (Fig. 7C). The gene discussed is WNT3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.