MYC and cancer: Our transcriptomic data and the pivotal roles of MYC in cancer and FBLN5 regulation [28, 29] led us to hypothesize that MYC might be a synthetic lethality partner of FBLN5. In order to test this hypothesis, we generated CV-1 cells stably transfected with MYC (CV-1 MYC cells) which exhibited traits typical of neoplastic transformation including change in morphology (Fig. 6a), loss of contact inhibition (Fig. 6b), shift in cell cycle distribution to S phase (Fig. 6c) and growth factor independent proliferation (Fig. 6d).