The protein-coding novel anticancer genes have a wide range of functional spectra: HYAL2 is a ubiquitous extracellular matrix hyaluronan-degrading enzyme [31], NEIL2 is involved in DNA base excision repair [32], YPEL4 is involved in cell proliferation [33], TMEFF2 is commonly methylated in numerous cancers and it is involved in diverse processes including neuroprotection [34]. Here, HYAL2 is linked to cancer.