Experimental overexpression of FBLN5 led to a 24.4% increase in cell death in CV-1 MYC cells relative to negative control (luc) whereas in native CV-1 cells, FBLN5 transfection caused a non-statistically significant increase of 4.3% in cell death pointing towards MYC being a synthetic lethality partner of FBLN5. To substantiate these results further, we knocked down MYC expression using shRNA by 40% in breast cancer MCF-7 cells, a cell line which expresses high levels of MYC [30], (Fig S9). This evidence concerns the gene FBLN5 and breast carcinoma.