In the latter case, a Lynch-like syndrome would be suspected, in which patients may meet the Amsterdam and Bethesda criteria, and present MSI and the absence of MMR proteins; however, these patients do not have identified germline mutations in the genes that encode proteins of the MMR system, and proposed explanations of this phenotype include the presence of cryptic or rare germline mutations in MMR genes, or even pathogenic germline mutations in genes like MUTYH, POLE and POLD1, the absence of the gene products of which could affect the MMR system [30]. The gene discussed is MRC1; the disease is Lynch syndrome.