While large bodies of evidence support the role of various inflammasome components, such as NLRP3, Caspase-1 (CASP-1), and Interleukin-1β (IL-1β) in AMD pathogenesis [5–8], the role of terminal inflammasome component pyroptotic pore-forming protein Gasdermin D (GSDMD) in the retina is currently not well-established. Here, GSDMD is linked to age-related macular degeneration.