GSDMD and retinal degeneration: Other studies support this role for GSDMD deficiency in protecting against retinal degeneration, with Sonny et al., (2023) demonstrating that GSDMD deficiency caused an overall reduction in retinal thinning and a decrease in total number of activated microglia/macrophages compared to WT littermates, in a hyperoxia induced model of retinopathy [56].