In this work, we investigated the potential role of GSDMD in photo-oxidative damage (PD)-induced retinal degeneration using an ENU-derived Gsdmd mutant strain-GsdmdI105N/I105N carrying an Ile to Asn amino acid substitution at position 105 (Fig. 1A, B), impairing the pore forming capacity of N-terminal GSDMD. The gene discussed is GSDMD; the disease is retinal degeneration.