As the activation and release of mature IL-1β has well-established roles in initiating and propagating inflammation in AMD [5, 8, 17, 18], including in macrophage recruitment [19], modulating chemokine expression [8], and in the activation of other pro-inflammatory cytokines, such as IL-6 [20]; understanding the role that GSDMD plays in the degenerating retina and how IL-1β is released and propagated far from the initial damage site is a key strategy in combating retinal inflammation, and slowing disease progression. The gene discussed is GSDMD; the disease is age-related macular degeneration.