GsdmdI105N/I105N mice were further found to have significantly reduced gene expression of inflammatory cytokines/chemokines known to play a role in AMD Il-1β, C3, Ccl2 and Gfap compared to WT controls following 5 days of PD (Fig. 1D, p < 0.05). The gene discussed is CCL2; the disease is age-related macular degeneration.