INS and metabolic dysfunction-associated steatotic liver disease: On the basis of our previous research, which reveals the importance of TAOK3 in the control of hepatocellular lipid partitioning in vitro, we here used the genetic model of high-fat diet-fed Taok3 whole-body knockout mice to decipher the possible in vivo role of this protein in metabolically-triggered NAFLD development and regulation of systemic glucose and insulin homeostasis.