Interestingly, even though this previous evidence points towards an important function of TAOK3 in hepatic metabolic dysfunction in NAFLD, here we failed to detect any in vivo phenotypic impact of whole-body TAOK3 knockout on the development of diet-induced NAFLD in mice, and the systemic glucose and insulin homeostasis was also unaffected. This evidence concerns the gene INS and metabolic dysfunction-associated steatotic liver disease.