Nevertheless, oncogenic transformation in vivo upon p53 loss happens predominantly in blood cells (lymphomas) and/or connective tissue (sarcomas), and these cancers are aneuploid (Funk et al. 2021; Liu et al. 2004; Tommasi et al. 2011; Chi et al. 2009; Baker et al. 2009; Foijer et al. 2014) (Table 1). The gene discussed is TP53; the disease is cancer.