Loss of p53 in HCT116 cells induces CIN only when combined with the loss of p73 (Schmidt et al. 2021) or loss of pRB (Manning et al. 2014), and the CIN seen upon TP53 knockout in human intestinal organoids was not accompanied by a significant increase in aneuploidy (Drost et al. 2015) (Table 1). This evidence concerns the gene RB1 and cervical squamous intraepithelial neoplasia.