TP53 and lymphoma: Induction of CIN by deleting the spindle assembly checkpoint (SAC) kinases Mps1 or Bub1 in mice heterozygous for functional p53 (p53 + / −) accelerated loss of heterozygosity (p53 − / −) and the development of aneuploid lymphomas (Foijer et al. 2014; Baker et al. 2009) (Table 1).