MAPK3 and melanoma: The results showed that 100 nM concentration of PLX8394 inhibited p-ERK1/2 levels after 4 h (Supplementary Fig. S1E) and after 18 h (Supplementary Fig. S1F) of inhibitor treatment, which is in accordance with previously published results obtained with V600EB-Raf mutated melanoma cell line [31].