This result was also consistent with two previous studies about PSMD2: silencing PSMD2 can reduce the cell proliferation and induce apoptosis in NSCLC cells [41]; transfection of PSMD2 cDNA can stimulate the growth of hepatoma cell line SMMC-7721 and mouse embryonic fibroblast NIH-3T3 [43]. Here, PSMD2 is linked to non-small cell lung carcinoma.