CD8A and viral infectious disease: Having found this major difference, we next fitted novel mechanistic models of viral dynamics to the data and explored multiple scenarios for the mechanisms of CD8+ cells’ action to control virus: (i) killing infected cells prior to viral integration; (ii) killing infected cells following viral integration (i.e., productively infected cells); and noncytolytically reducing viremia through indirect mechanisms, such as (iii) reducing the rate of viral infection or (iv) reducing the rate of viral production.