PD1-related checkpoints were highly related to pyroptosis activities in different cancer types, including Programmed Cell Death 1 (PD-1, PDCD1), Programmed Cell Death 1 Ligand 1 (PD-L1, CD274), and Programmed Cell Death 1 Ligand 2 (PDCD1LG2). The gene discussed is PDCD1; the disease is cancer.