Furthermore, regarding tumor types of the genitourinary tract, PPI was significantly positive associated with M1 macrophages infiltration in ACC (R = 0.44), Tregs infiltration in KIRC (R = 0.36), CD8 + T cells infiltration in KIRP (R = 0.21), and activated NK cells infiltration in TGCT (R = 0.34), respectively (Fig. 4c). The gene discussed is CD8A; the disease is neoplasm.