TMEM107 and cyst: We found ∼50% down-regulation of TMEM107 gene expression as determined by RT–qPCR in the presence of DOX (Fig S6C) that led to alterations in primary cilia formation including extremely elongated or very short cilia with expanded bulges in their tip (Fig S6D), cyst formation inside of the organoids (Fig S6B), and failure to form NR structures in retinal organoids (Fig S6E), thus corroborating the results generated using the knock-out approach.