Fig 2A illustrates the number of cell lines available for different cancer lineages in CRISPR and shRNA screens. Pathways information from the KEGG database was considered as specific network elements associated with either pan-cancer or different cancer types (Table S1). Pathways of ERK, PI3K, WNT, Hedgehog, NOTCH, TGFB, JAK-STAT, calcium, HIF-1, cell cycle, apoptosis, KEAP1, nuclear receptor, telomerase activity were among those considered for the pan-cancer analysis (hsa05200; Fig 2B). The gene discussed is MAPK1; the disease is cancer.