We speculate that this is due to the rapid loss of VEGF-A podocyte production in the mature glomerulus as this is common to both our model and also the previous work by Eremina et al.13 Understanding the dynamic regulation of podocyte VEGF-A production in differing kidney diseases should be pursued in more detail to understand how this key, podocyte-produced, growth factor27,28 regulates glomerular function. The gene discussed is VEGFA; the disease is kidney disorder.