TP53 and infection: p53 is generally considered an inducer of apoptosis in many viruses-infected cells, however the previous reports suggested that during HSV-1 infection, p53 plays both positive and negative roles in HSV-1 replication; upregulating ICP27 expression, early during the infection and downregulation of ICP0 at later stages of infection, inhibit apoptosis during the HSV infection.