Since C-peptide is associated with insulin, which plays an important role in maintaining metabolic homeostasis in the body, including metabolic regulation of muscle tissue [11], and the prevalence of skeletal sarcopenia was significantly higher in elderly diabetic patients than in non-elderly diabetic patients [12], we hypothesized that there might be an association between C-peptide and skeletal sarcopenia in elderly diabetic patients. This evidence concerns the gene INS and sarcopenia.