Integrin αvβ3 is necessary for tumor cell adhesion to the extracellular matrix (ECM) by targeting RGD (Arg-Gly-Asp) in fibronectin and regulates MMP (especially MMP-2 and MMP-9) expression through the PI3K signaling pathway to hydrolyze collagen in the ECM [19]. The gene discussed is FN1; the disease is neoplasm.