CD8A and neoplasm: Interestingly, we found that integrin αvβ3/α6β1 was negatively associated with immune functions, including APC co-stimulation, cytolytic activity, T-cell co-stimulation and the type II IFN response, and integrin αvβ3/α6β1 was negatively correlated with most immune functional cells, including DCs, B cells, NK cells, CD8+ T cells, mast cells, Th cells, macrophages, and other tumor infiltrating lymphocytes (TILs) (Figure 1A).