ITGA6 and posterior cortical atrophy: In our study, a heatmap was established to clearly observe the expression levels of integrin αvβ3/α6β1 and clinical characteristics, including PSA value, primary therapy outcome success, pathological T and N stages, Gleason score, treatment success and clinical T and N stages, of 496 PCa patients in the TCGA cohort, and the results implied that integrins ITGAV, ITGA6, ITGB1 and ITGB3 were closely associated with these clinical features (Figure 2A).