Besides, three major pathways are involved in MAPK pathway including extracellular signal-related kinase (ERK), the stress-activated protein kinase/Jun-N-terminal kinase (SAPK/JNK) and the p38 MAPK and an interesting target for developing anticancer drugs is ERK [18, 19] Existing research has suggested that ERK is correlated with osteosarcoma progression. Here, MAPK8 is linked to osteosarcoma.