Approximately, 1 in 300 to 500 people in the population will carry a PV in either BRCA1 or BRCA2 (BRCA; the genes most commonly associated with hereditary breast and ovarian cancer (HBOC)) [3–6], and 1 in 370 individuals will carry a pathogenic variant (PV) in one of the Lynch syndrome genes (the genes most commonly associated with hereditary colorectal cancer) [7]. This evidence concerns the gene BRCA2 and Hereditary breast and ovarian cancer syndrome.