In this context, European guidelines recommend an upper limit of normal in the non-acute setting of 35 pg/mL for BNP and 125 pg/mL for NT-proBNP, as these values have a very high negative predictive value (from 0.94 to 0.98) and values under these levels make a diagnosis of HF very unlikely [6]. Here, NPPB is linked to hydrops fetalis.