Indeed, fat tissues are metabolic/endocrine organ that secretes adipokines, chemokines, and proinflammatory cytokines such as tumour necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6), and others, thus play an important role related to obesity, and inflammation [48]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.